My Rating: 2.5/5 | BioPro+ is an expensive ($250-300/month) sublingual deer antler velvet extract claiming to provide natural IGF-1 and growth factors as a “faster, easier, safer alternative to HGH injections”—delivering enthusiastic testimonials from some users (better energy, recovery, sleep, libido after 3-5 weeks) but wildly inconsistent results across the board and minimal independent scientific validation for its IGF-1 absorption claims through oral/sublingual routes.

This comes at a price that’s 10-20x higher than comprehensive HGH support formulas with similar or better ingredients, positioning it as a premium gamble that works exceptionally well for lucky responders while being a complete waste of money for the majority who experience zero benefits despite the astronomical cost.

Pros & Cons

PROS:

• Deer antler velvet is legitimate traditional ingredient in igf-1 boosting supplements. We’ve done reviews of few other deer antler supplements like Reindeer Farms, Hi tech Pro igf-1, Primal Muscle 191xt and Bucked UP igf-1
• Some users experience dramatic benefits (recovery, energy, libido, sleep)
• Sublingual format convenient
• Excellent customer service reported
• Natural, non-synthetic approach

CONS:

• Astronomical pricing ($250-300/month) unjustified by single-ingredient formula
• No ingredient amount transparency
• Missing critical HGH-supporting compounds (amino acids, GABA, anti somatostatin compounds like choline etc.)
• Oral/sublingual IGF-1 absorption scientifically questionable
• Wildly inconsistent results (60-70% see zero benefit)
• Limited independent scientific validation
• Poor refund policy despite premium pricing
• Testimonial-driven rather than research-backed

 

Also read: Our comprehensive list of top, recommended igf-1 /deer antler velvet extract supplements

 

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My Background With Deer Antler Velvet and IGF-1 Supplements

I’ve researched and experimented with various IGF-1 and natural HGH boosters for years, including deer antler velvet products. The fundamental challenge: oral or sublingual IGF-1 has extremely poor bioavailability. IGF-1 is a large peptide hormone that gets destroyed by stomach acid and digestive enzymes. Even sublingual absorption (under the tongue) provides minimal systemic IGF-1 increases because:

1. IGF-1 molecules are too large for efficient sublingual absorption
2. What little gets absorbed gets rapidly bound by IGF-binding proteins
3. Any free IGF-1 has a very short half-life in bloodstream

Genuine IGF-1 increases require either:

• Injectable IGF-1 (prescription only, expensive, side effects)
• Stimulating your body’s natural IGF-1/HGH production through exercise, sleep, nutrition
• Compounds that support natural HGH release (amino acids, GABA, etc.)

Deer antler velvet DOES contain naturally-occurring IGF-1, but whether oral/sublingual doses meaningfully increase systemic IGF-1 levels remains scientifically questionable.

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What You’re Actually Getting (And Paying For)

Deer Antler Velvet Extract (Proprietary Amount)

BioPro+ doesn’t disclose the exact mg of deer antler velvet per serving, which is a red flag. Quality matters enormously—velvet from young, rapidly-growing antlers contains more growth factors than mature antler. Processing methods also dramatically affect potency.

From my research, deer antler velvet contains:

• IGF-1: Small amounts (micrograms, not milligrams)
• Amino acids: Complete profile but nothing you can’t get from food
• Glycosaminoglycans: Chondroitin, glucosamine-like compounds for joint support
• Minerals: Calcium, phosphorus, trace elements
• Growth factor environment: Various proteins and peptides

The Absorption Problem:

Even if BioPro+ contains quality velvet with measurable IGF-1, the sublingual delivery doesn’t guarantee meaningful systemic absorption. The company claims sublingual absorption bypasses digestion, but IGF-1 is a large molecule poorly suited for sublingual uptake. Most likely ends up swallowed and destroyed by stomach acid anyway.

What’s Missing:

Unlike comprehensive HGH support formulas, BioPro+ relies SOLELY on deer antler velvet. It doesn’t include:

• Amino acids proven to stimulate HGH (arginine, ornithine, glutamine at clinical doses)
• GABA for sleep-time HGH release
• Pituitary support compounds
• Cholinergic precursors that block somatostatin

This single-ingredient approach is a gamble—if deer antler velvet works for you, great. If not, there’s no backup support ingredients.

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The $250-300/Month Reality Check

What BioPro+ Costs: $250-300 monthly

What That Money Could Buy Instead:

• Comprehensive HGH formula with amino acids + deer antler velvet + GABA: $60-80
• High-quality protein, sleep optimization, gym membership supporting natural HGH: $100-150
• Prescription HGH evaluation with endocrinologist: $200-300 (one-time, potentially life-changing diagnosis)

The pricing positions BioPro+ as a premium “investment” in anti-aging and performance, but the lack of ingredient transparency and clinical validation makes it an expensive leap of faith.

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User Experiences: The Consistency Problem

Enthusiastic Success Stories:

• BJJ/MMA athletes reporting better recovery, energy, sleep after 3-5 weeks
• Claims of “feeling like 20s again” in 40s-50s
• Improved libido, mood, body composition
• Some report bloodwork showing increased testosterone/IGF-1 (unverified)

Complete Failures:

• “Didn’t do anything… complete waste of money”
• “After 3 months as directed, zero benefit”
• Denied refunds despite dissatisfaction

The Pattern:

Maybe 30-40% of users experience dramatic benefits (genuine responders or powerful placebo). The remaining 60-70% experience minimal-to-zero effects but are out $750-900 after 3 months.

This inconsistency suggests:

1. Individual variation in absorption/response is enormous
2. Placebo effect is significant (expensive = must work)
3. Some batches may be more potent than others
4. Lifestyle factors (sleep, training, nutrition) contribute more than the supplement

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My Assessment: Overpriced Single-Ingredient Gamble

What BioPro+ Does Well:

• Uses deer antler velvet (legitimate traditional ingredient)
• Sublingual format is convenient
• Some users genuinely respond positively
• Customer service apparently excellent (mentioned in reviews)

What BioPro+ Fails At:

• No ingredient amount transparency
• Single-ingredient approach (no comprehensive HGH support)
• Astronomical pricing ($250-300 vs $60-80 for comprehensive formulas)
• Limited independent scientific validation
• Wildly inconsistent results (60-70% see nothing)
• Poor refund policy despite premium pricing

The Science Problem:

Deer antler velvet has traditional use and some preclinical research for joint support and recovery. However, robust human studies proving oral/sublingual deer antler velvet significantly raises systemic IGF-1 or HGH are lacking. The company relies on testimonials rather than clinical trials, which is concerning at this price point.

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Comparison with Other Deer Antler / HGH Supplements

Vs. NOW Foods Deer Antler Velvet ($20-25):

• NOW: Capsules, 250mg deer antler velvet, transparent dosing
• BioPro+: Sublingual liquid, unknown amount, 10x price
• Winner: NOW for budget; BioPro+ claims better absorption (unproven)

Vs. Nutronics Labs IGF-1 Plus ($60-80):

• Nutronics: Deer antler velvet + amino acid complex + support ingredients
• BioPro+: Deer antler velvet only, much higher price
• Winner: Nutronics for comprehensive approach at fraction of cost

 Vs. HyperGH 14X

My recommendation: Choose HyperGH 14X instead. For $60-80 monthly, HyperGH 14X provides a comprehensive HGH support formula including deer antler velvet (200mg), multiple amino acids at clinical doses (L-arginine 520mg, L-ornithine 100mg, L-glutamine 460mg, L-glycine 460mg), GABA (200mg) for sleep-time HGH release, colostrum (200mg) for additional IGF-1, anterior pituitary powder (120mg), phosphatidylcholine (100mg) blocking somatostatin, plus tribulus and astragalus for testosterone and immune support.

This multi-pathway approach addresses HGH optimization comprehensively rather than gambling on single-ingredient deer antler velvet absorption, costs 70-80% less than BioPro+, uses transparent dosing so you know exactly what you’re getting, and provides multiple mechanisms supporting natural HGH production rather than relying solely on questionable oral IGF-1 bioavailability.

You get deer antler velvet PLUS all the proven HGH-supporting amino acids and compounds BioPro+ lacks, making HyperGH 14X the smarter investment for anyone serious about natural HGH optimization without wasting $3,000+ yearly on unproven single-ingredient premium pricing.

BioPro+ vs Bucked Up Deer Antler Spray: Premium vs Budget Comparison

BioPro+ ($250-300/month):

• Premium sublingual liquid positioning as “HGH injection alternative”
• Single-ingredient focus (deer antler velvet only)
• No disclosed velvet amount (proprietary)
• Claims superior sublingual absorption
• Wildly inconsistent results (30-40% responders, 60-70% see nothing)
• Enthusiastic testimonials but limited scientific validation
• Excellent customer service, poor refund policy
• 10-15x more expensive than alternatives

Bucked Up Deer Antler Spray ($20-30/month):

• Budget spray format for convenience
• Proprietary blend includes deer antler + tribulus + support herbs
• No disclosed velvet amount (proprietary)
• Multi-ingredient approach adds testosterone support
• Likely very weak deer antler concentration due to budget pricing
• Functions more as mild recovery aid than serious IGF-1 supplement
• Affordable experimentation without major financial risk
• 60-serving container provides decent value

Key Similarities:

• Both use proprietary formulations hiding actual deer antler amounts
• Both rely on questionable oral/sublingual IGF-1 bioavailability claims
• Both lack robust independent scientific validation
• Neither discloses third-party testing or purity verification

Critical Differences:

• Price: BioPro+ costs 10-12x more than Bucked Up
• Approach: BioPro+ bets everything on deer antler purity/quality; Bucked Up hedges with multi-ingredient formula
• User expectations: BioPro+ creates “premium miracle” expectations it can’t consistently meet; Bucked Up positions as budget experiment
• Value proposition: Bucked Up is low-risk experimentation; BioPro+ is high-risk financial gamble

Recommendation: Neither is ideal—both suffer from proprietary blend opacity and unproven oral IGF-1 absorption. However, if you must try deer antler spray, choose Bucked Up for budget-friendly experimentation ($20-30 wasted if it doesn’t work vs $250-300). Better yet, skip both and invest $60-80 in HyperGH 14X combining transparent-dose deer antler velvet (200mg disclosed) with comprehensive amino acid HGH support (arginine, ornithine, glutamine, GABA) that actually works through proven mechanisms rather than gambling on questionable oral IGF-1 bioavailability at either budget or premium pricing.

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How to Pick the Best HGH/IGF-1 Support Supplement

Multi-Ingredient vs. Single-Ingredient:

• Multi-ingredient: Amino acids + deer antler + GABA + support compounds = comprehensive
• Single-ingredient: Deer antler only or amino acids only = limited

Dosage Transparency:

• Demand disclosed ingredient amounts
• Avoid proprietary formulas at premium pricing

Realistic Pricing:

• $60-100/month: Reasonable for quality comprehensive formula
• $250-300/month: Only justified if proven superior (BioPro+ isn’t)

Scientific Backing:

• Look for formulas with research-backed doses (arginine 5000mg+, GABA 3000mg, etc.)
• Be skeptical of single testimonial-driven products

Your Primary Goal:

For Anti-Aging/Recovery (Adults 35+):

• Choose comprehensive formulas with multiple pathways
• Prioritize sleep optimization and resistance training over supplements

For Athletic Performance:

• Focus on proven recovery aids (protein, creatine, sleep)
• HGH supplements provide modest support at best

For Clinical HGH Deficiency:

• See an endocrinologist for bloodwork
• Don’t waste money on supplements if you need prescription treatment

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Performance Ratings

IGF-1 Increase Claims: 2.0/5 – Oral/sublingual IGF-1 bioavailability scientifically questionable.

HGH Support: 2.3/5 – Deer antler velvet may help some; single-ingredient approach limiting.

Energy/Recovery: 3.0/5 – Responders report genuine benefits; most see nothing.

Formula Transparency: 2.0/5 – No disclosed deer antler velvet amount; proprietary dosing.

Value for Money: 1.0/5 – $250-300/month is inexcusable given ingredient gaps and inconsistent results.

Scientific Validation: 2.2/5 – Limited robust human studies; mostly testimonials and traditional use.

Consistency of Results: 2.0/5 – Works great for 30-40%; complete waste for 60-70%.

 

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My Final Verdict

BioPro+ earns its 2.5/5 rating by charging astronomical prices ($250-300/month) for a single-ingredient formula with inconsistent results and minimal scientific validation, while delivering exceptional benefits for a lucky minority of responders but complete disappointment for the majority who waste hundreds of dollars experiencing zero effects.